Bloodroot (Sanguinaria canadensis) is a perennial, herbaceous flowering plant native to eastern North America from Nova Scotia, Canada southward to Florida, United States. It is the only species in the genus Sanguinaria, and is included in the family Papaveraceae and most closely related to Eomecon of eastern Asia. The blood of the root (when cut open) was used as a dye and was used for a herbal remedy by the native population. A break in the surface of the plant, especially the roots, reveals a reddish sap.

Bloodroot is a plant. People use the underground stem (rhizome) to make medicine.

Bloodroot is used to cause vomiting, empty the bowels, and reduce tooth pain. It is also used to treat croup, hoarseness (laryngitis), sore throat (pharyngitis), poor circulation in the surface blood vessels, nasal polyps, achy joints and muscles (rheumatism), warts, and fever.

Some people apply bloodroot directly to the skin around wounds to remove dead tissue and promote healing. During the mid-1800s, bloodroot extracts were applied to the skin as part of the Fell Technique for treatment of breast tumors.

In dentistry, bloodroot is used on the teeth to reduce the build-up of plaque. Plaque is a film of saliva, mucus, bacteria, and food particles that can promote gum disease.

Bloodroot contains chemicals that might help fight bacteria, inflammation, and plaque.