Name: Osthole

CAS:484-12-8 

Molecular formula:C15H16O3

Molecular weight:244.28574

Description:Osthol is an O-methylated coumarin. It is a calcium channel blocker which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.

Osthole - also spelled osthol - is a type of coumarin. It is found in cnidium monnieri and several other plants. Osthol may increase androgen, gonadotropin and nitric oxide synthase (NOS) activity. One mouse study indicates osthol had androgen like effect and gonadotropin like effect. Little research has been done with osthole, however it appears that this substance may have a role to play in liver health, brain function, and vasodilation.

Benefits

Osthole benefit for fatty liver

Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.

Planta Med. 2007.

The objectives of this study were to determine the therapeutic effect of osthole, an active constituent isolated from Cnidium monnieri, in hyperlipidemic fatty liver rats and investigate the possible mechanism of the osthole treatment. Osthole exerts therapeutic effects on fat milk-induced fatty liver in rats, by regulating mRNA expression of the target genes of CYP7A, DGAT, L-FABP and FATP4 via increasing the PPARalpha/gamma mRNA expression.

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